4011 ADVANCED ORGANIC CHEMISTRY EXPERIMENTATION
This course provides experimental experience in organic chemistry at an advanced level. Lectures and seminars will accompany the experimental work.
Prereq: Registration in (or completion of) two other fourth year courses other than 4021.

4021 ADVANCED PHYSICAL/ INORGANIC CHEMISTRY EXPERIMENTATION
This course provides experimental experience in physical/organic chemistry at an advanced level. Lectures and seminars will accompany the experimental work.
Prereq: Registration in (or completion of) two other fourth year courses other than 4011.

4101 SYNTHETIC ORGANIC CHEMISTRY
The synthesis of complex organic molecules is discussed with special emphasis on the strategy of organic synthesis (synthetic design). Examples from the literature will be discussed to exemplify approaches to the construction of complex carbon frameworks, the use of blocking groups and the sterochemical aspects of organic reactions. The application of spectroscopic techniques to the characterization of products and intermediates, the choice of separation methods and the use of the chemical literature are also discussed.
Prereq: Chemistry 3151; or permission of the Department.

4111 PHYSICAL ORGANIC CHEMISTRY
This course deals with the effects of molecular structure and environment on reaction rates in terms of reaction transition states. Topics discussed include thermodynamics, kinetics, methods of elucidating reaction pathways, linear free energy relationships and salt, pH and kinetic isotope effects. Special topics, included as time permits, are aromaticity, resonance and molecular orbital theory, the role of molecular orbital symmetry in electrocyclic reactions and photochemistry.
Prereq: Chemistry 3141, 3211 and 3221; or permission of the Department.

4121 THEORETICAL ORGANIC CHEMISTRY
Zeroth order symmetry - simplified Hückel and molecular orbital calculations are developed. Calculations are extended to heteroatom - substituted and Möbius structures. This course includes an introduction to chemical graph theory.
Prereq:Mathematics 1121, Chemistry 3151; or permission of the Department.

4131 ORBITAL SYMMETRY AND ORGANIC REACTIONS
Several approaches to the analysis of reactions which are subject to control by orbital symmetry will be presented including (i) the Zimmerman-Dewar m ethod, (ii) frontier orbital arguments and (iii) the construction of correlation diagrams. The course will survey selected classes of reactions including (i) electrocyclic reactions, (ii) cycloadditions, (iii) sigmatropic rearrangements, (iv) cheletropic explusions and (v) carbene insertions.
Prereq: Chemistry 4121; or permission of the Department.

4201 STATISTICAL THERMODYNAMICS
The course develops the theory of statistical thermodynamics from the statistical distribution of the energy of particles using the Maxwell-Boltzmann distribution law. Partition functions and degeneracy are calculated from the various contributions to the total energy for simplified models of actual systems. Thermodynamic quantities are then derived in terms of partition functions. The derived equations are used in a general discussion of quantum effects, the canonical ensemble, the transition state theory, adsorption and catalysis.
Prereq: Chemistry 3211, 3221, and Math 2121; or permission of the Department.

4211 MACROMOLECULAR CHEMISTRY
The course will emphasize that natural and synthetic macromolecules are the commonest organic materials we encounter in a non-laboratory setting. After illustrating what is presently known about the structures of common macromolecules it will look at the history of the "macromolecular hypothesis". Previous studies in "kinetics and mechanism", encountered in several other courses, will lead into a consideration of the reactions of synthesis and decomposition of macromolecules. Then the techniques of classical and statistical thermodynamics will be applied to interpret the behaviour of macromolecules in solution and in the various solid phases (rubbers, glasses and fibers) in which macromolecules are found
Prereq: Chemistry 2141 and 3221; or permission of the Department.

4221 ADVANCED KINETICS
This course further develops the concepts of chemical kinetics introduced in Chemistry 2221. Mechanistic schemes are developed more generally and in greater detail. Special attention is paid to the Activated Complex Theory, its variations, ramifications and applications. Fast reaction and relaxation techniques are discussed, especially in regard to solution kinetics.
Prereq: Chemistry 3221, or permission of the Department.

4311 INORGANIC CHEMISTRY IV: PHYSICAL ASPECTS
The main content of the course will involve applications of group theory in inorganic chemistry for molecular bonding, IR and Roman spectroscopic transitions for small molecules and ions, and crystal field theory. Fourier transform techniques for IR and miltinuclear NMR will also be introduced.
Prereq: Chemistry 3311, and 3411; or permission of the Department.

4351 INORGANIC CHEMISTRY V: BIOINORGANIC CHEMISTRY
The biological chemistry of metal ions is discussed with special emphasis on the chemical principles that are important for biochemical processes. Basic kinetic and thermodynamic principles in metallobiochmistry will be addressed as will topics such as transport and storage, regulation, redox pathways, chemotherapeutics, oxygen carriers, experimental metheds, and metal complexes aas probes for structures and reactivity.
Prereq: Chemistry 3311; or permission of the Department.

4701 STRUCTURE DETERMINATION
This is a course in structural chemistry, especially the theory and interpretation involved in using instrumental methods to elucidate the structures of inorganic and organic compounds. The methods used will include: Magnetic resonance, mass spectroscopy, infrared and Raman spectroscopy, and X-ray, neutron, and electron diffraction.
Prereq: Chemistry 3141 and 3311; or permission of the Department.

4801 SPECIAL TOPICS IN CHEMISTRY
This course provides an opportunity for a student to undertake the study of a topic in which he/she has a special interest. The programme of study will be jointly planned by the student and a faculty member and might involve combinations of reading and seminars. A written report is required at the completion of the work, which can be carried out in one term or throughout the academic year for three credits.
Prereq: Agreement of an instructor, and permission of the Department.

4990 THESIS
To meet the requirements for the Chemistry Honours degree, student are given the opportunity to undertake a research project under the supervision of a Faculty member. This research is normally carried out in the summer preceding the final year. A Thesis based on this research is written for submission to the Dean of Science and is presented orally to the Department.
Prereq: Permission of the Department.

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